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The Cornell Daily Sun
Wednesday, Dec. 10, 2025




CALS Quad

Research Spotlight: Locus Coeruleus Degeneration and Its Pathological Role in Alzheimer's Disease

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The locus coeruleus (LC) — a tiny, ancient brainstem structure that regulates arousal, attention and memory—plays a far more critical role in cognition and disease than long assumed, and its early deterioration is now recognized as a key marker of Alzheimer’s progression. Emerging interventions such as vagus nerve stimulation and even music-based therapies may help modulate LC function, offering promising avenues for preserving cognitive health as we age.