As an undergraduate studying mechanical engineering, Lewis was interested in anything with an engine — his friends described him as a “gearhead.” But Lewis also found that within the realm of mechanical engineering, the number of unasked questions seemed limited compared to those in biology.
From middle school biology we were always taught that the nucleus is the “control center” of the cell, similar to how the brain is the control center of our own bodies. At first glance this makes a lot of sense, considering the nucleus contains DNA — the genetic code of life — and a good amount of the machinery that is required to transcribe this code into the proteins that make up our being. Despite this seemingly intuitive role of the nucleus, a recent study conducted by the Prof. Jan Lammerding, biomedical engineering, and post-doctoral fellow Tyler Kirby, suggests the nucleus may also act as a “mechano-sensor” in the cell. A mechano-sensor is a component of the cell that responds to physical stimuli in the environment of the cell, such as touch, charge, or temperature. Previously the role of mechano-sensor was credited entirely to cell membrane proteins.