Humans have a long and complicated history with gluten. Celiac disease was first described in 1888 and identified as early as the 1000 CE. Celiac disease is an autoimmune condition where gluten causes an immune inflammation in the small intestine, leading to discomfort. Celiacs need to completely and permanently avoid any form of gluten in their diets. Though not incredibly common, people have paid a lot of attention to this gluten-free lifestyle.